Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction
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چکیده
منابع مشابه
Exosomes Secreted by Normoxic and Hypoxic Cardiosphere-derived Cells Have Anti-apoptotic Effect
Cardiosphere-derived cells (CDCs) have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are required for the regenerative effects of human CDCs and mimic the cardioprotective benefits of CDCs such as anti-apoptotic effect in animal myocardial infarction (MI) models. Here we aimed to investigate the anti-apoptotic effect of the hypoxic and normoxic...
متن کاملExosomes Secreted by Normoxic and Hypoxic Cardiosphere-derived Cells Have Anti-apoptotic Effect
Cardiosphere-derived cells (CDCs) have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are required for the regenerative effects of human CDCs and mimic the cardioprotective benefits of CDCs such as anti-apoptotic effect in animal myocardial infarction (MI) models. Here we aimed to investigate the anti-apoptotic effect of the hypoxic and normoxic...
متن کاملCellular postconditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.
BACKGROUND Intracoronary delivery of cardiosphere-derived cells (CDCs) has been demonstrated to be safe and effective in porcine and human chronic myocardial infarction. However, intracoronary delivery of CDCs after reperfusion in acute myocardial infarction has never been assessed in a clinically-relevant large animal model. We tested CDCs as adjunctive therapy to reperfusion in a porcine mode...
متن کاملIntramyocardial injection of heart-derived extracellular matrix combined with cardiosphere-derived cells improves myocardial structure and function in rats with acute myocardial infarction
This study aimed to investigate the cardioprotective effects of intramyocardial injection of heart derived extracellular matrix (ECM) and cardiosphere-derived cells (CDCs) in a rat model of myocardial infarction (MI). ECM and CDCs were collected from the rat heart, and the proliferation, apoptosis and morphology of CDCs maintained on ECM were characterized in vitro. MI model was established in ...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2016
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehw240